TORONTO (Bloomberg) — Canada's main stock index fell from a record after profits at some US companies missed analysts' estimates, signalling slower economic growth that may crimp demand for Canadian commodities.The S&P/TSX has climbed 27 percent in the past year on demand for energy and raw materials in China, the world's biggest consumer of commodities, and the US, Canada's biggest trading partner. The index fell for the first time in four days after China raised interest rates to cool growth and US companies, such as Caterpillar Inc., reported profits shy of analysts' estimates.

"The poor results south of the border have probably given people a reason to sell," said David Cockfield, who helps manage $2 billion at Leon Frazer & Associates in Toronto. "The whole soft spot in a relatively positive picture continues to be the United States."

Canada's S&P/TSX Composite Index fell 42.89, or 0.3 percent, to 14,582.87 in Toronto. The index has risen three consecutive weeks, gaining 0.6 percent this week.

Biovail Corp. led the decline, plunging 21 percent after regulators rejected the drugmaker's application for approval of an antidepressant. The shares lost C$5.64 to C$20.95, the biggest drop since August. The US Food and Drug Administration questioned studies needed for the approval of a new, once-daily formulation of Wellbutrin XL, also known as bupropion, Biovail said.

Technology companies in the S&P/TSX fell one percent for the second biggest drop after health care stocks among 10 industry groups. Research In Motion Ltd. declined for the first time in four days, slipping C$2.44 to C$241.90.

The Globe and Mail reported earlier this month that Research In Motion won permission to sell its BlackBerry e-mail phones in China, the world's biggest mobile phone market by subscribers. Nortel Networks Co., North America's biggest maker of telephone equipment, slid 40 cents to C$25.60.

Falling natural gas prices pushed down shares of energy producers. EnCana Corp., Canada's largest natural-gas producer, dropped 73 cents to C$66.75. Nexen Inc., an oil and natural-gas company, slipped 30 cents to C$35.55. Natural gas prices dropped the most since February, losing 32 cents, or 4.8 percent, to $6.39 at 4:27 p.m. in New York electronic trading.