OKLAHOMA CITY — A tornado carved a devastating path through an eastern Colorado town as a massive spring storm swept from the Rockies into the central Plains, killing at least four people in three states, authorities said yesterday.Sixty-five tornadoes were reported in Oklahoma, Texas, Kansas, Colorado and Nebraska on Wednesday, the National Weather Service said.

One twister killed an Oklahoma couple as it blew their home to pieces. Another woman died after the Colorado tornado hit, and a Texas man was found dead in the tangled debris of his trailer.

The massive storm system stretched from South Dakota to Texas yesterday morning, threatening flash flooding in central Nebraska and Kansas and more severe weather farther south.

Winter storm warnings were still posted for most of Wyoming, where heavy snow was blamed for interstate highway pileups, forecasters said. In central Wyoming’s Wind River Mountains, 58 inches of snow from the storm was recorded by yesterday morning.

Some of the worst devastation was in Holly, Colorado, 235 miles southeast of Denver, where at least eight people were injured when the tornado plowed through the town late Wednesday. Dozens of homes were damaged and the streets and yards were littered with broken power lines, tree limbs and debris.

A 28-year-old woman whose home was hit in the Holly area died after being airlifted to a Colorado Springs hospital, Coroner Joe Giadone said yesterday.

The Colorado tornadoes also killed dozens of cattle, and injured others so severely they will have to be shot, rancher Bill Lowe said. “It’s better than letting them suffer,” he said.

Just three months earlier, back-to-back blizzards and subzero temperatures killed more than 10,000 animals on farms across Holly’s southeastern corner of the state.

At least 11 tornadoes were reported throughout western Nebraska, destroying or damaging three homes and 10 to 12 miles of power lines, emergency management officials said. Two tornadoes touched down in far northwest Kansas, severely damaging three homes, the Cheyenne County sheriff’s department said.

Near Elmwood, Oklahoma, Vance and Barbra Woodbury were killed when the storm blew apart their home, said Dixie Parker, Beaver County’s emergency management director. Their bodies were found about 75 feet from the obliterated structure.

The Texas Panhandle was hit with baseball-sized hail, rain and tornadoes that uprooted trees, overturned trucks and injured at least three people. Monte Ford, 53, was killed near Amarillo when he was thrown about 15 feet from his oilfield trailer, which was rolled by the wind, Department of Public Safety spokesman Dan Hawthorne said.

The wintry weather closed a 250-mile stretch of Interstate 80 in southern Wyoming. Large parts of Interstate 25 and more than 80 miles of I-90 were also closed.