CLEVELAND (AP) – Derek Anderson threw five touchdown passes, Jamal Lewis rushed for 215 yards and the Cleveland Browns, so desperate after losing their home opener they traded their starting quarterback, outlasted the Cincinnati Bengals and Carson Palmer 51-45 yesterday.

Anderson had a breakout game against the Browns (1-1), going 20-of-33 for 328 yards and the five TDs, which tied a team record shared by Frank Ryan, Bill Nelsen, Brian Sipe and Kelly Holcomb.

Palmer went 33-of-50 for 401 yards and tossed a career-high six TDs, but his final chance to rally the Bengals (1-1) ended when he was intercepted with 21 seconds left by Leigh Bodden, who made a diving grab near Cleveland's sideline.

It was just the third time in NFL history that two QBs threw five TD passes in the same game. Oakland's Tom Flores (6) and Houston's George Blanda (5) both did it on December 22, 1963, and Billy Kilmer of New Orleans (6) and Charley Johnson of St. Louis (6) also did on November 5, 1969.

Packers 35, Giants 13

At East Rutherford, New Jersey, Brett Favre completed his first 14 passes of the second half and threw three touchdown passes to rally Green Bay over Eli Manning and New York.

The victory was the 149th of Favre's 17-year NFL career, giving him one more win than Hall of Famer John Elway.

It also gave the Packers their first 2-0 start since they won their first three in 2001.

The loss was the second straight for the undisciplined and error-prone Giants, something that hasn't happened at the start of a season since 1996.

Texans 34, Panthers 21

At Charlotte, North Carolina, Matt Schaub threw for 227 yards and two touchdowns and Houston forced three turnovers to recover from a sluggish start and go 2-0 for the first time in franchise history.

Houston went 24-56 in its first five years with David Carr, who was released in the off-season when the Texans traded for Schaub. Carr, now the Panthers back-up, could only watch as Andre Johnson caught seven passes for 120 yards and two scores, Ahman Green rushed for 71 yards and a TD and the Texans rallied from a 14-0 deficit. They handed the Panthers (1-1) their fourth consecutive loss in their home opener.

Colts 22, Titans 20

At Nashville, Tennessee, Peyton Manning threw for 312 yards and a touchdown, and Indianapolis held off Tennessee when its defense stopped Vince Young on a final-drive comeback.

Unlike last December, when Rob Bironas capped a similar comeback with a 60-yard field goal, the Colts collapsed around Young on fourth-and-four. That forced him to lob the ball away in the final seconds.

Manning, 28-of-42, kneeled down to run out the final seconds as champion Indianapolis (2-0) reminded Tennessee (1-1) which team remains atop the AFC South. Adam Vinatieri had one of his worst days in years despite making field goals of 22, 39 and 20 yards. He had an extra point blocked and a field goal partially blocked that bounced off the crossbar before going over. He also missed a 36-yarder.

49ers 17, Rams 16

At St. Louis, Dante Hall fumbled while catching a punt and Marcus Hudson recovered for San Francisco, setting up the winning field goal by Joe Nedney.

The Rams' Jeff Wilkins missed a 56-yard field goal try with 59 seconds to play, the ball falling about a yard short of the goal post.

The 49ers (2-0) won despite struggling offensively most of the game. St. Louis (0-2) had 392 total yards to 186 for San Francisco. Alex Smith was 11-for-17 for 126 yards. Frank Gore scored two touchdowns and gained 81 yards on 20 carries.

Buccaneers 31, Saints 14

At Tampa, Florida, Joey Galloway caught four passes for 135 yards and two touchdowns, tormenting New Orleans for the sixth straight game between the NFC South rivals and leading the Buccaneers to a victory.

The Saints (0-2) were embarrassed for the second consecutive week and have been outscored 72-24 after having one of the NFL's most explosive offences and reaching the NFC championship game last season.

Steelers 26, Bills 3

At Pittsburgh, Willie Parker ran for a touchdown and 126 yards, and Ben Roethlisberger threw for a score as Pittsburgh controlled the clock and the tempo while pulling away from Buffalo. It was the Bills' first game since tight end Kevin Everett badly injured his spinal cord.

Jaguars 13, Falcons 7

At Jacksonville, Florida, Joey Harrington was sacked seven times as Jacksonville held Atlanta under 100 yards rushing.

Atlanta's biggest problem came on special teams, where rookie Matt Prater missed two field goals. His second miss yesterday would have given the Falcons (0-2) a 10-3 advantage. Instead, David Garrard drove Jacksonville (1-1) on consecutive scoring drives to put the team ahead for good.

Cardinals 23, Seahawks 20

Maybe that Cardinals curse is history. After blowing a 17-0 lead in what looked like another classic Arizona collapse, Darnell Dockett recovered a fumble by Seattle's Matt Hasselbeck. Then Neil Rackers kicked a 41-yard field goal with one second to go Sunday, giving the Cardinals a 23-20 victory over the Seahawks. Rackers' 52-yarder tied it at 20 with 4:44 to play.

Bears 20, Chiefs 10

Devin Hester fielded the punt, and in a flash, the Chicago Bears were in control. Hester scored on a 73-yard punt in the second quarter and set up a field goal in the third with another long return as the defending NFC champions beat the Kansas City Chiefs 20-10.

Cowboys 37, Dolphins 20

The Dallas Cowboys did plenty of scoring again yesterday, this time with help from their defence. After winning a shootout in the season opener, Dallas took advantage of five takeaways and a ball-control offense to beat the hapless Miami Dolphins 37-20. The Cowboys intercepted Trent Green four times and recovered a fumbled snap. Green also fumbled attempting a spike play late in the first half, possibly costing Miami points.

Lions 20, Vikings 17

The Minnesota Vikings and Detroit Lions took turns blowing chances to win the game. In the end, Jason Hanson's 37-yard field goal in overtime lifted Detroit to a 20-17 victory over Minnesota and ended a ten-game losing streak in the series. The Lions and Vikings combined for nine turnovers in regulation — and two missed field goal attempts in the final 35 seconds.

Broncos 23, Raiders 20

The Denver Broncos may never have called a smarter timeout. Jason Elam's 23-yard field goal with 5:48 left in overtime gave the Broncos a 23-20 win just minutes after the Raiders had been celebrating what they thought was their own wild win. Sebastian Janikowski nailed a 52-yard field goal at 11:13 of overtime. But as the Raiders rushed the field in celebration and the Broncos hung their heads in defeat, the officials ruled Denver called a timeout just before the snap.

Ravens 20, Jets 13

In a duel of back-up quarterbacks, Kyle Boller's experience prevailed over Kellen Clemens' exuberance. Barely. Boller threw for 185 yards and two touchdowns and the Baltimore Ravens overcame a late charge by Clemens and the New York Jets in a 20-13 victory.