Fantasy managers have several decisions to make as the next international break looms within the next week or so. For example, the defensive pairing of Cristian Romero and Micky van de Ven will be missing for Tottenham for at least a few weeks through suspension and injury respectively.

Tyrick Mitchell and Joachim Anderson of Crystal Palace could be transferred into your squad and do an equally important job at the back.

Saturday

Wolverhampton Wanderers v Tottenham Hotspur (8.30am)

Wolves conceded a stoppage-time winner at Sheffield United to end an unbeaten run of five games. Hugo Bueno, Joe Hodge and Pedro Neto are out through injury this weekend for the West Midlands club.

Tottenham suffered their first defeat of the campaign to rivals Chelsea on Monday, with Cristian Romero and Destiny Udogie (second yellow) sent off; Udogie will miss one game and Romero three through suspension. Alfie Whiteman, Ivan Perisic, Ryan Sessegnon and Manor Solomon are out through injury, while Ben Davies, Micky van de Ven and James Maddison are doubtful.

Tottenham edge this rivalry with 9 wins to Wolves’s six from 18 league meetings.

Prediction: 1-1

Arsenal v Burnley (11am)

Arsenal were narrowly beaten at Newcastle last week to drop to fourth place. Jurrien Timber, Thomas Partey, Emile Smith-Rowe and Gabriel Jesus are out through injury, while Martin Odegaard is doubtful with a hip problem.

Burnley remain in the bottom three after starting with just one win from their first 11 games. Hjalmar Ekdal is out with a knee injury, while Manuel Benson, Aaron Ramsey, Lyle Foster and Michael Obafemi are doubtful.

Arsenal have won 11 of 16 top-flight meetings with the Clarets.

Prediction: 3-0

Crystal Palace v Everton (11am)

Crystal Palace cruised past Burnley last time out to soar to eleventh place. Dean Henderson, James Tomkins, Michael Olise, and Jesurun Rak-Sakyi are out to injury this week.

Everton have had a resolute start to the campaign, with five of their six defeats by just one goal. Seamus Coleman, Andre Gomes and Dele Alli are out through injury, with Amadou Onana doubtful with a calf injury.

Everton dominate this rivalry with 13 wins to Palace’s six in 28 Premier League contests.

Prediction: 0-2

Manchester United v Luton Town (11am)

Manchester United held off Fulham to stop a run of five losses in their last eight league matches. Tyrell Malacia, Lisandro Martinez, Luke Shaw, Amad Diallo and Casemiro are out with injury this week.

Luton picked up a valuable point in the home draw with Liverpool last Sunday. Mads Juel Andersen, Amari Bell, Reece Burke, Dan Potts, Albert Sambi Lokonga, Luke Berry and Jordan Clark are out through injury this match for the Hatters.

This is the first Premier League meeting between these clubs.

Prediction: 2-0

Bournemouth v Newcastle United (1.30pm)

Bournemouth remain in the relegation zone after their hammering by Manchester City last week. Neto, Ryan Fredericks, Emiliano Marcondes and Tyler Adams are out to injury, while Alex Scott is doubtful.

Newcastle scraped a controversial home win over Arsenal to stay in touch with the leaders. Bruno Guimaraes is suspended for yellow card accumulation, while Sven Botman, Dan Burn, Matt Targett, Elliott Anderson, Jacob Murphy, Harvey Barnes and Alexander Isak are out to various injuries. Javier Manquillo, Alex Murphy and Callum Wilson are doubtful.

The Magpies edge this series with four wins to Bournemouth’s two through ten contests.

Prediction: 1-3

Sunday

Aston Villa v Fulham (10am)

Aston Villa maintain their best Premier league start despite the defeat at Nottingham Forest last week. Tyrone Mings, Emiliano Buendia and Jacob Ramsey are out to injury, while Jhon Duran is doubtful with a toe problem.

Fulham could not finish their chances in the home loss to Manchester United. Issa Diop is out to a foot injury, while Kenny Tete, Tosin Adarabioyo, Adama Traore and Rodrigo Muniz are doubtful for the trip to Villa Park.

Villa lead this rivalry with 12 wins to Fulham’s seven in 30 encounters.

Prediction: 2-2

Brighton & Hove Albion v Sheffield United (10am)

Brighton are winless in their last five league matches and the strain of Europe could now be taking its toll on domestic results. The Seagulls will be without Tariq Lamptey, Julio Enciso, Solly March and Danny Welbeck to injury, while Jakub Moder is doubtful owing to lack of fitness.

Sheffield United gained their first victory via a 100th-minute winner last weekend. Anel Ahmedhodzic, Chris Basham, John Egan, Max Lowe, Rhys Norrington-Davies, Tom Davies, Daniel Jebbison and Oliver McBurnie are out injured, while Goncalo Hamer and Rhian Brewster are doubtful.

United are unbeaten in four games against the Seagulls.

Prediction: 2-0

Liverpool v Brentford (10am)

Liverpool were punished for missing clear-cut chances in the draw at Luton. Alexis Mac Allister is suspended to yellow card accumulation, Andy Robertson, Stefan Bajcetic and Thiago Alcantara are out through injury, while Curtis Jones is doubtful this week.

Brentford are now on a three-game winning streak. Rico Henry, Aaron Hickey, Mikkel Damsgaard, Josh DaSilva, Keane Lewis-Potter and Kevin Schade are out to injury, while Shandon Baptiste and Mark Flekken are doubtful.

The Reds edge this series with two wins to Brentford’s one through 4 meetings.

Prediction: 3-1

West Ham United v Nottingham Forest (10am)

West Ham have stumbled to one win in their last five games, but Kurt Zouma is the only injury absentee for the Hammers this week.

Forest cruised past Aston Villa for their best win of the campaign last Sunday. Chris Wood, Divock Origi and Callum Hudson-Odoi are out to injury, while Felipe, Gonzalo Montiel and Harry Toffolo are doubtful.

The Hammers have won five of ten league meetings with Forest.

Prediction: 2-2

Chelsea v Manchester City (12.30pm)

Chelsea trounced London rivals Spurs to kick-start their season on Monday. Trevoh Chalobah, Ben Chilwell, Wesley Fofana, Carney Chukwuemeka, Romeo Lavia and Christopher Nkunku are out this weekend to injury, while Armando Broja is doubtful with a knee injury.

Manchester City have quickly responded to consecutive league defeats by returning to the top after the home win over Bournemouth. Kevin de Bruyne is out with a hamstring injury, while John Stones, Manuel Akanji and Sergio Gomez are doubtful this weekend.

The Blues dominate this historic rivalry with 27 wins from 52 encounters, though City have won four of the last five contests.

Prediction: 1-3